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| Registros recuperados : 28 | |
| 10. |  | MATIAS, M.; GARCIA, M. V.; AGUIRRE, A. de A. R.; ANDREOTTI, R. Identificação da ixodofauna em área urbana e rural da cidade de Campo Grande, MS. In: INTERNATIONAL SYMPOSIUM ON TICK CONTROL AND TICK-BORNE DISEASES, 2013, Campo Grande, MS. [Proceedings..]. Campo Grande, MS: Embrapa Gado de Corte, 2013. (Embrapa Gado de Corte. Documentos, 202). Comissão organizadora: Renato Andreotti, Fernando Paiva, Wilson Werner Koller, Jacqueline Cavalcante Barros, Luiz Antonio Dias Leal, Jaqueline Matias.| Biblioteca(s): Embrapa Gado de Corte. |
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| 11. | | SANTOS, J. M. dos; MATIAS, J.; GARCIA, M. G.; AGUIRRE, A. de A. R.; ANDREOTTI, R. Identificação da Ixodofauna e detecção de Rickettsia spp. em área rural da cidade de Terenos, MS. In: CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 49., 2013, Campo Grande, MS. Anais... Campo Grande: SBMT, 2013.| Biblioteca(s): Embrapa Gado de Corte. |
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| 13. | | AGUIRRE, A. de A. R.; GARCIA, M. V.; CUNHA, R. C.; ANDREOTTI, R. Reverse vaccinology approach to develop an anti- tick vaccine. In: INTERNATIONAL SYMPOSIUM ON TICK CONTROL AND TICK-BORNE DISEASES, 2013, Campo Grande, MS. [Proceedings..]. Campo Grande, MS: Embrapa Gado de Corte, 2013. (Embrapa Gado de Corte. Documentos, 202). Comissão organizadora: Renato Andreotti, Fernando Paiva, Wilson Werner Koller, Jacqueline Cavalcante Barros, Luiz Antonio Dias Leal, Jaqueline Matias.| Biblioteca(s): Embrapa Gado de Corte. |
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| 14. | | BLECHA, I. M. Z.; CSORDAS, B. G.; AGUIRRE, A. de A. R.; CUNHA, R. C.; GARCIA, M. V.; ANDREOTTI, R. Analysis of Bm86 conserved epitopes: is a global vaccine against Cattle Tick Rhipicephalus microplus possible? Revista Brasileira de Parasitologia Veterinária, Jaboticabal, v. 27, n. 3, p. 267-279, july.-sept. 2018 Título em português: Análise de epítopos conservados da Bm86: é possível uma vacina global contra Carrapato-do-Boi Rhipicephalus microplus?| Biblioteca(s): Embrapa Gado de Corte. |
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| 15. | | GARCIA, M. V.; SANTOS, J. M. dos; AGUIRRE, A. de A. R.; JUAN, M. P.; ANDREOTTI, R. Amblyomma coelebs (Neumann 1899: Acari; Ixodidae) parasitando humanos no Estado de Mato Grosso do Sul, Brasil. In: CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 50., 2014, Rio Branco., Anais... Rio Branco: SBMT, 2014. 1 p.| Biblioteca(s): Embrapa Gado de Corte. |
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| 16. | | AGUIRRE, A. de A. R.; RODRIGUES, V. da S.; COSTA, I. N. da; GARCIA, M. V.; HIGA, L. de O. S.; MEDEIROS, J. F.; ANDREOTTI, R. Biological parameters of Amblyomma coelebs Neumann, 1906 (Acari: Ixodidae) under experimental conditions. Revista Brasileira de Parasitologia Veterinária, Jaboticabal, v. 27, n. 1, p. 80-85, jan.-mar. 2018 Título em português: Parâmetros biológicos de Amblyomma coelebs Neumann, 1906 (Acari: Ixodidae) em condições experimentais.| Biblioteca(s): Embrapa Gado de Corte. |
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| 17. | | GARCIA, M. V.; ANDREOTTI, R.; REIS, F. A.; AGUIRRE, A. de A. R.; BARROS, J. C.; MATIAS, J.; KOLLER, W. W. Contributions of the woolless sheep as a host for the maintenance of Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) populations in a pasture area in Brazil. Parasites & Vectors, London, v. 18, n. 1, p. 1-4, Nov. 2014.| Biblioteca(s): Embrapa Caprinos e Ovinos; Embrapa Gado de Corte. |
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| 18. | | GARCIA, M. V.; ANDREOTTI, R.; REIS, F. A.; AGUIRRE, A. de A. R.; BARROS, J. C.; MATIAS, J.; KOLLER, W. W. Contributions of the hair sheep breed Santa Ines as a maintenance host for Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) in Brazil. Parasites & Vectors, v. 7, n. 515, 2014| Biblioteca(s): Embrapa Gado de Corte. |
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| 19. | | MATIAS, J.; GARCIA, M. V.; CUNHA, R. C.; AGUIRRE, A. de A. R.; BARROS, J. C.; CSORDAS, B. G.; ANDREOTTI, R. Spotted fever group Rickettsia in Amblyomma dubitatum tick from the urban area of Campo Grande, Mato Grosso do Sul, Brazil. Ticks and Tick-borne Diseases, v. 6, n. 2, p. 107-110, 2015| Biblioteca(s): Embrapa Gado de Corte. |
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| 20. | | AGUIRRE, A. de A. R.; RODRIGUES, V. da S.; COSTA, I. N. da; GARCIA, M. V.; HIGA, L. de O. S.; BLECHA, I. M. Z.; DUARTE, P. de O.; CSORDAS, B. G.; MEDEIROS, J. F.; ANDREOTTI, R. Biological parameters of Amblyomma coelebs Neumann, 1906 (Acari: Ixodidae) under experimental conditions. In: Congresso da Sociedade Brasileira de Medicina Tropical, 53., 2017, Cuiabá. Ambiente e doenças tropicais: desafios para campos e cidades. Campinas: Embra Embra Serviços em Tecnologia Ltda EPP, 2017.| Biblioteca(s): Embrapa Gado de Corte. |
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| Registros recuperados : 28 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Gado de Corte. |
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Data corrente: |
29/03/2016 |
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Data da última atualização: |
28/03/2017 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
AGUIRRE, A. de A. R.; LOBO, F. P.; ANDREOTTI, R. |
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Afiliação: |
ANDRÉ DE ABREU RANGEL AGUIRRE, FAMEZ/UFMS; FRANCISCO PEREIRA LOBO, CNPTIA; RENATO ANDREOTTI E SILVA, CNPGC. |
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Título: |
Design of the ATAQ peptide and its evaluation as an immunogen to develop a Rhipicephalus vaccine. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Veterinary Parasitology, v. 221, p. 30-38, 2016 |
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Idioma: |
Inglês |
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Conteúdo: |
Tick infestation may cause several problems including affecting domestic animal health and reducing the production of meat and milk, among others. Resistance to several classes of acaricides have been reported, forcing researchers to search for alternative measures, such as vaccines against ticks, to ensure tick control while having no or at least low negative impacts on the environment and public health. However, the current commercially available vaccines in different strains of Rhipicephalus microplus are reported to be of low efficacy. Fortunately, reverse vaccinology approaches have shown positive results in the new generation of vaccines. On this basis, a synthetic peptide from the ATAQ protein, which is present in the gut and Malpighi tubes of R. microplus, was synthesized. The ATAQ proteins were isolated, characterized and sequenced from several species of the genus Rhipicephalus. The alignment showed 93.3% identity among DNA sequences of ATAQs from these species. Because of this, immunization trials with this peptide were conducted on mice, rabbits and cattle to evaluate the humoral immune response and the efficacy against Rhipicephalus sanguineus in addition to R. microplus. Based on recent results, we conclude that reverse vaccinology is a promising approach because it is more accurate and faster than conventional methods in the detection of potential antigens to use in anti-tick vaccines. It is not only applicable against R. microplus but also against tick species that play important roles in spreading other diseases. ATAQ proteins should be considered as the antigen in new trials to develop a multi-antigenic vaccine. Although these peptides behave as hapten and are not able to be recognized by the immune system on its own, using carriers and adjuvants helps its presentation and induces strong immune responses. Furthermore, an efficiency of 35% reduction in overall life cycle parameters was reported for R. microplus (98% for ELISA responder animals) and 47% for R. sanguineus. Although not yet enough to prevent the environment to infestation of ticks, this still constitutes a promising strategy that could be applied to integrated measures on tick control and in new research that develops anti-tick vaccines. MenosTick infestation may cause several problems including affecting domestic animal health and reducing the production of meat and milk, among others. Resistance to several classes of acaricides have been reported, forcing researchers to search for alternative measures, such as vaccines against ticks, to ensure tick control while having no or at least low negative impacts on the environment and public health. However, the current commercially available vaccines in different strains of Rhipicephalus microplus are reported to be of low efficacy. Fortunately, reverse vaccinology approaches have shown positive results in the new generation of vaccines. On this basis, a synthetic peptide from the ATAQ protein, which is present in the gut and Malpighi tubes of R. microplus, was synthesized. The ATAQ proteins were isolated, characterized and sequenced from several species of the genus Rhipicephalus. The alignment showed 93.3% identity among DNA sequences of ATAQs from these species. Because of this, immunization trials with this peptide were conducted on mice, rabbits and cattle to evaluate the humoral immune response and the efficacy against Rhipicephalus sanguineus in addition to R. microplus. Based on recent results, we conclude that reverse vaccinology is a promising approach because it is more accurate and faster than conventional methods in the detection of potential antigens to use in anti-tick vaccines. It is not only applicable against R. microplus but also against tick specie... Mostrar Tudo |
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Palavras-Chave: |
ATAQ; Reverse vaccinology; Synthetic peptide. |
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Thesaurus NAL: |
Immunization; Rhipicephalus microplus; Rhipicephalus sanguineus. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/158239/1/Design-of-the-ATAQ-peptide-and-its-evaluation.pdf
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Marc: |
LEADER 02914naa a2200217 a 4500
001 2041997
005 2017-03-28
008 2016 bl uuuu u00u1 u #d
100 1 $aAGUIRRE, A. de A. R.
245 $aDesign of the ATAQ peptide and its evaluation as an immunogen to develop a Rhipicephalus vaccine.$h[electronic resource]
260 $c2016
520 $aTick infestation may cause several problems including affecting domestic animal health and reducing the production of meat and milk, among others. Resistance to several classes of acaricides have been reported, forcing researchers to search for alternative measures, such as vaccines against ticks, to ensure tick control while having no or at least low negative impacts on the environment and public health. However, the current commercially available vaccines in different strains of Rhipicephalus microplus are reported to be of low efficacy. Fortunately, reverse vaccinology approaches have shown positive results in the new generation of vaccines. On this basis, a synthetic peptide from the ATAQ protein, which is present in the gut and Malpighi tubes of R. microplus, was synthesized. The ATAQ proteins were isolated, characterized and sequenced from several species of the genus Rhipicephalus. The alignment showed 93.3% identity among DNA sequences of ATAQs from these species. Because of this, immunization trials with this peptide were conducted on mice, rabbits and cattle to evaluate the humoral immune response and the efficacy against Rhipicephalus sanguineus in addition to R. microplus. Based on recent results, we conclude that reverse vaccinology is a promising approach because it is more accurate and faster than conventional methods in the detection of potential antigens to use in anti-tick vaccines. It is not only applicable against R. microplus but also against tick species that play important roles in spreading other diseases. ATAQ proteins should be considered as the antigen in new trials to develop a multi-antigenic vaccine. Although these peptides behave as hapten and are not able to be recognized by the immune system on its own, using carriers and adjuvants helps its presentation and induces strong immune responses. Furthermore, an efficiency of 35% reduction in overall life cycle parameters was reported for R. microplus (98% for ELISA responder animals) and 47% for R. sanguineus. Although not yet enough to prevent the environment to infestation of ticks, this still constitutes a promising strategy that could be applied to integrated measures on tick control and in new research that develops anti-tick vaccines.
650 $aImmunization
650 $aRhipicephalus microplus
650 $aRhipicephalus sanguineus
653 $aATAQ
653 $aReverse vaccinology
653 $aSynthetic peptide
700 1 $aLOBO, F. P.
700 1 $aANDREOTTI, R.
773 $tVeterinary Parasitology$gv. 221, p. 30-38, 2016
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Embrapa Gado de Corte (CNPGC) |
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